Full site

Bipolar androgen therapy, explained.

A 28-day oscillation between two poles — supraphysiologic and near-castrate testosterone — designed to keep prostate cancer from adapting to a single hormonal environment. This site covers the Hopkins-style CRPC protocol, every named trial in the book, and adaptive BAT for hormone-sensitive disease.

How the shock works Adaptive BAT for HSPC See the trials

28-day oscillation

Two poles, one cycle

Illustrative curve for testosterone cypionate 400 mg IM every 28 days while ADT continues. Not a patient’s labs.

High pole often 1,000–3,000 ng/dL in the first days. Trough often 100–200 ng/dL by day 28. Next injection restarts the swing. Stop ADT and you no longer have BAT — you have replacement.

What this site is

CRPC evidence plus HSPC aBAT

Mechanism and the dishonest PSA narrator
Hopkins-style 400 mg / 28-day protocol
All 26 book trials, filterable
A full page on adaptive BAT in hormone-sensitive disease